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Dr. Mabuse the Gambler (German: Dr. Mabuse, der Spieler) is the first film in the Dr. Mabuse series, about the character Doctor Mabuse who featured in the novels of Norbert Jacques. It was directed by Fritz Lang and released in 1922. The film is silent and filmed mostly 16 frames per second. It would be followed by The Testament of Dr. Mabuse (1933) and The Thousand Eyes of Dr. Mabuse (1960).

It is about four hours long and divided into two parts: Der große Spieler: Ein Bild der Zeit and Inferno: Ein Spiel von Menschen unserer Zeit. The title, Dr. Mabuse, der Spieler, is ambiguous. Der Spieler means the player in German, and can be translated as the gambler, the actor, or the puppeteer. Dr. Mabuse, who disguises, plays with emotions and tricks other people, is probably all of them in some sense.